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بحث جديد للدكتور عثمان حجاوي ينشر في مجلة علمية بريطانية عريقة

بحث في قصور القلب قام به الدكتور عثمان حجاوي بمشاركة عدد من الباحثين

بحث جديد للدكتور عثمان حجاوي ينشر في مجلة علمية بريطانية عريقة بعنوان:

Taurine blunts doxorubicin cardiotoxicity: chronic and acute effects

وكان البحث مختصا في قصور القلب قام به الدكتور عثمان حجاوي بمشاركة عدد من الباحثين وقد نال الموافقة على النشر من قبل الكونغرس الأوربي للأبحاث وسيتم نشره من قبل مجلة بريطانية علمية عريقة تصدر بشكل سنوي في لندن

رقم المجلد

Europace 2021 Volume 23 Supplement 3
Basic Science – Cardiac Diseases

أسماء المشاركين في البحث:

Cobet V.: Tacu L.1: Hajawi 0.2 Rotaru V.1: Frasineac V.: Braniste A.

State University of Medicine and Pharmacy, C, M (Republic of) 2 Aleppo University, Faculty of
Medicine in the liberated areas, Medicine , Aleppo, Syrian Arab Republic
Funding Acknowledgements: Type of funding sources: None. Aim. To study the functional statement
of the isolated heart inherent to doxorubicin cardiotoxicity under the chronic and acute action of
taurine
Material and methods. Doxorubicin (Dx) cardiotoxicity manifested by heart failure development was
reproduced classically by anthracycline i/p administration in rats in cumulative dose of 16 mg/kg (4
mg/kg four times during 2 weeks) – Dx series. Series with chronic action of taurine (Tr) included rats
receiving this aminoacid daily per os during Dx administration (100 mg/kg) – Dx + Tr series. Rats of
both series were sacrificed by euthanasia and the isolated heart was perfused by Krebs solution
according to Langendorff (isovolumic heart) and Neely-Rovetto (working heart) methods in conditions
of diverse hemodynamic and neuroendocrine efforts applying. Acute action of taurine was studled
during its infusion in the perfusate of isolated hearts in final concentration of 40 MM. The hearts of
intact rats constituted the control series
Results. Chronic action of taurine has identified certain important functional benefits, the most
important being underlined beneath. The first, taurine reversed the negative inotropic effect of isolated
heart on endothelin-1 (ET-1) action (10-7 M), detected in Dx series and manifested by both systolic
pressure of left ventricle (LV) and cardiac output fall by about 9,1%. Taurine assured increase of these
indices during ET-1 stimulation. The second, Tr notably improved both isovolumic relaxation and
contraction of myocardium exhibited by significant enhancement of Veragut index (118,69,6 vs 94,8
16,5 1/sec), +dP/dPmax (8389 445 vs 7216 363 mm Hg/sec) and -dP/dTmax (7526 378 vs 5684 322
mm Hg/sec) during efforts with volume and resistance. The third, Tr significantly decreased LV end
diastolic pressure (LVSDP) when coronary pressure of isovolumic heart elevated by 50% (from 80 up
to 120 cm H20 column): 16,2 +1.2 vs 18,8 11,4 mm Hg. Acute Traction manifested by: (i) significant
LVSDP diminution during 30 min of ischemia (52,4+3,1 vs 63,724,4 mm Hg) and on 45th min of
reperfusion (18,3 1,3 vs 22,81,4 mm Hg). (6) increased time of LV extrasystole appearance when the
glucose content of Krebs solution was reduced by 50% (28,6 +2,8 vs 22,5+2,4 min), and (ii) increased
time of LV tachyarrhythmia appearance when the potassium content of Krebs solution raised up to 6,5
meq/L (9,2 +0,5 vs 6,9 +0,3 min).
Conclusion. Taurine, a natural calcium modulator of the heart, notably improves functional reserves of
the myocardium exposed to cardiotoxic action of Dx, and could be seen as a relevant remedy of
primary and secondary prophylaxis of Dx induced heart failure in oncologic patients.

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